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Diets Sabotaged in the Brain & Atkins Diet for Alzheimer's?
Source:
http://www.medpagetoday.com/LabNotes...&userid=215607 Lab Notes: Diets Sabotaged in the Brain By MedPage Today Staff Published: June 24, 2011 Battle of the Bulge Rages in the Brain Concerted, but unsuccessful, efforts to lose weight might indicate that the brain has thrown up a neurochemical roadblock, according to a study involving obese mice. After a 24-hour fast, lean mice lost 18% of their body weight, whereas their roly-poly counterparts lost only 5%. Laboratory studies showed that the obese animals did not exhibit downregulation of genes that activate the interleukin-1 system and associated anti-inflammatory cytokines, as reported in Obesity. "Our data show that fasting induces an anti-inflammatory effect on a lean animal's neuroimmune system, and that effect is inhibited by a high-fat diet," Gregory G. Freund, MD, of the University of Illinois in Urbana, said in a statement. "Some of the brain-based chemical changes that occur in a lean animal simply don't occur in an obese animal." On the basis of the findings, Freund cautioned against beginning a weight-loss effort with a fast or "cleansing day," as that may trigger alterations in the immune system preventing weight loss. Investigators also found that fasting adversely affected obese animals' activity level and behavior. As compared with lean animals, the fat ones moved around less, had altered burrowing activity, and generally exhibited signs of anxiety and depression, possibly reflecting another alteration in brain chemistry and providing another reason for caution about beginning weight loss with a fast. -- C.B. Atkins Diet for Alzheimer's? In the 1920s, the ketogenic diet was a popular way to relieve epileptic seizures. While drugs have mostly replaced the therapeutic diet, it is still used for those refractory to drugs. Now, researchers say they've figured out why it works and also how it may help in neurodegenerative diseases. According to a report in the July issue of the Journal of Clinical Investigation, mouse experiments showed that the diet increased activation of adenosine A1 receptors, which helped to suppress seizures. Previous research had suggested the diet could be beneficial in other neurodegenerative disorders including Alzheimer's disease and Parkinson's disease. "There is evidence that adenosine deficiency might also be a pathological hallmark of Alzheimer's. Adenosine deficiency can lead to both seizures [and] cognitive impairment," senior author Detlev Boison, PhD, of the Legacy Research Institute in Portland, Ore., told MedPage Today. "Interestingly, seizures are a comorbidity of Alzheimer's and cognitive deficiency is a comorbidity of epilepsy. Based on this rationale and the fact that a ketogenic diet augments adenosine signaling in the brain, a ketogenic diet should be effective in Alzheimer's disease as well," said Boison. -- C.K. |
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Diets Sabotaged in the Brain & Atkins Diet for Alzheimer's?
pamela quoted:
Source: http://www.medpagetoday.com/LabNotes...&userid=215607 Atkins Diet for Alzheimer's? By this they mean ketotic eating in general not the 4 phase Atkins plan. Previous research had suggested the diet could be beneficial in other neurodegenerative disorders including Alzheimer's disease and Parkinson's disease. This was a speculation a while ago. Their were also studies of milder ketotic eating plans for epileptics - The idea on that is the old suggestion was a no-carb plan but that milder ketotic plans should work just as well. "There is evidence that adenosine deficiency might also be a pathological hallmark of Alzheimer's. Adenosine deficiency can lead to both seizures [and] cognitive impairment," senior author Detlev Boison, PhD, of the Legacy Research Institute in Portland, Ore., told MedPage Today. "Interestingly, seizures are a comorbidity of Alzheimer's and cognitive deficiency is a comorbidity of epilepsy. Based on this rationale and the fact that a ketogenic diet augments adenosine signaling in the brain, a ketogenic diet should be effective in Alzheimer's disease as well," said Boison. Thanks! |
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Diets Sabotaged in the Brain & Atkins Diet for Alzheimer's?
pamela quoted:
Source: http://www.medpagetoday.com/LabNotes...&userid=215607 "Our data show that fasting induces an anti-inflammatory effect on a lean animal's neuroimmune system, and that effect is inhibited by a high-fat diet," Gregory G. Freund, MD, of the University of Illinois in Urbana, said in a statement. "Some of the brain-based chemical changes that occur in a lean animal simply don't occur in an obese animal." This part is strange. The reduced water retention of ketotic plans tend to reduce inflamation and ketotic plans tend to be high fat. I don't think they have a low carb set of test subjects. |
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Diets Sabotaged in the Brain & Atkins Diet for Alzheimer's?
On Jun 27, 2:39*pm, Doug Freyburger wrote:
pamela quoted: Source: http://www.medpagetoday.com/LabNotes..._content=&utm_.... "Our data show that fasting induces an anti-inflammatory effect on a lean animal's neuroimmune system, and that effect is inhibited by a high-fat diet," Gregory G. Freund, MD, of the University of Illinois in Urbana, said in a statement. "Some of the brain-based chemical changes that occur in a lean animal simply don't occur in an obese animal." This part is strange. *The reduced water retention of ketotic plans tend to reduce inflamation and ketotic plans tend to be high fat. *I don't think they have a low carb set of test subjects. I'd say issuing recommendations about how humans should start or not start their diets based on this one small study of mice is even stranger. |
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Quote:
The mission of the Atkins Diet Bulletin Board (ADBB) is to make a positive difference in the lives of those who have adopted the controlled carbohydrate lifestyle by providing information and support through a world leading international weight loss and open discussion forum, and by creating a nurturing educational environment that fosters effective communication and maximizes the potential of each member to achieve lifelong weight-loss and health. Our underlying values are founded on the Atkins approach to weight loss from the 2002 edition of Dr. Atkins New Diet Revolution (2002 DANDR), which we believe to be the safest and most nutritionally efficient method in existence. |
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