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Study Details Link Between Obesity, Carbs and Esophageal Cancer
Esophageal cancer rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001.
The headline is probably overstated.... there is a statistical association here, not a cause and effect. ================================================== === http://www.blackwellpublishing.com/p...m.asp?ref=1632 Study Details Link Between Obesity, Carbs and Esophageal Cancer As Obesity and Carb-intake Rates Have Increased, So Has Specific Cancer Cleveland, Ohio – February 25, 2008 – Cases of esophageal cancer (adenocarcinoma) in the U.S. have risen in recent decades from 300,000 cases in 1973 to 2.1 million in 2001 at age-adjusted rates. A new study published in The American Journal of Gastroenterology shows that these rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001. The study illustrates what may be a public heath concern as the composition of U.S. diets changes and total carbohydrate and refined carbohydrate intakes increase. Obesity is a risk factor for many types of cancer, and a diet that includes a high percentage of calories from refined carbohydrates is a common contributor to obesity. Carbohydrates were also unique in that no other studied nutrients were found to correlate with esophageal cancer rates. The causes of esophageal cancer remain largely unknown. Despite recent advances in treatment, esophageal cancer has a poor prognosis. The five-year rate of survival for esophageal cancer remains below 20 percent and is the eighth-leading cause of cancer related death in American men. “If we can reverse the trends in refined carbohydrate intake and obesity in the U.S., we may be able to reduce the incidence of esophageal cancer,” says Dr. Li Li, senior author of the study. __________________________________________________ _______________ This study is published in The American Journal of Gastroenterology. Media wishing to receive a PDF of this article may contact . Dr. Li Li is an Assistant Professor in the Department of Family Medicine and Case Comprehensive Cancer Center at Case Western Reserve University/University Hospitals Health System. Dr. Li can be reached for questions at . The American Journal of Gastroenterology is the official publication of the American College of Gastroenterology, and the #1 clinical journal in gastroenterology. The journal brings a broad-based, interdisciplinary approach to the study of gastroenterology, including articles reporting on current observations, research results, methods of treatment, drugs, epidemiology, and other topics relevant to clinical gastroenterology. For more information, please visit www.blackwellpublishing.com/ajg. The American College of Gastroenterology (ACG) was founded in 1932 to advance the scientific study and medical practice of diseases of the gastrointestinal (GI) tract. The College promotes the highest standards in medical education and is guided by its commitment to meeting the individual and collective needs of clinical GI practitioners. For more information, please visit www.acg.gi.org. ================================================= Abstract and link to full text below, for those who have managed to read this far. ================================================= http://www.amjgastro.com/showContent...ype=abstra ct Carbohydrate Consumption and Esophageal Cancer:An Ecological Assessment Cheryl L. Thompson, Ph.D. 1,2, Vijay Khiani, M.D. 3, Amitabh Chak, M.D. 3, Nathan A. Berger, M.D. 3, and Li Li, M.D., Ph.D. 1,2 Affiliations 1Departments of Family Medicine 2Epidemiology and Biostatistics 3Medicine, Transdisciplinary Research on Energetics and Cancer Program, Case Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio OBJECTIVES: The incidence of esophageal adenocarcinoma is on the rise in the United States. In this ecological study using the Surveillance, Epidemiology, and End Results (SEER) program (1973–2001) and national food consumption data (1909–1997), we evaluated the correlation between secular trends of dietary macronutrient intakes and esophageal cancer rates. METHODS: Linear regressions were performed to assess the correlation between age-adjusted incidence rates of esophageal cancers and nutrients. RESULTS: The increase in esophageal adenocarcinoma was found to be strongly correlated with the rise in carbohydrate intake (P 0.0001). The decline in squamous cell carcinoma rates was negatively correlated with carbohydrate intake in the univariate model (P 0.0001), but this correlation disappeared when adjusted for other nutrients. Correlations of esophageal adenocarcinoma to percentage of calories from corn syrup, representing refined carbohydrates, were statistically significant in the univariate model (P 0.0001), but decreased in significance in the multivariate model (P = 0.0118). We also found a significant correlation between obesity and esophageal adenocarcinoma (P 0.0001) during the same time period. CONCLUSION: Our ecological evaluation suggests that high carbohydrate intake and obesity can account for at least some of the rise in esophageal adenocarcinoma. Within-population studies are needed to clarify these trends. (Am J Gastroenterol 2007;102:1-7) |
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Study Details Link Between Obesity, Carbs and Esophageal Cancer
On Feb 26, 7:56 am, Jim wrote:
Esophageal cancer rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001. The headline is probably overstated.... there is a statistical association here, not a cause and effect. ================================================== === http://www.blackwellpublishing.com/p...m.asp?ref=1632 Hrm. Let's see if we can come up with a causative story. Just there is correlation doesn't mean there ISN'T causation. When I eat too many carbs, I, like many people, get vary degrees of acid reflux. We might prove this one by looking at sales of antacids and acid blockers against carb consumption, but from my own experience (and the related clinical experience of Dr. Atkins and the Eadeses), we're pretty sure about this. Carbs cause acid reflux. Stomach acid where it doesn't belong cannot be a good thing. It hurts. But could it be doing damage, effectively diverting the immune system from fighting newlyn tumors? I'm not disagreeing about the headline probably being over stated, but at the same time, it's pretty easy to see how it might work. |
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Study Details Link Between Obesity, Carbs and Esophageal Cancer
Hollywood wrote:
On Feb 26, 7:56 am, Jim wrote: Esophageal cancer rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001. The headline is probably overstated.... there is a statistical association here, not a cause and effect. ================================================== === http://www.blackwellpublishing.com/p...m.asp?ref=1632 Hrm. Let's see if we can come up with a causative story. Just there is correlation doesn't mean there ISN'T causation. When I eat too many carbs, I, like many people, get vary degrees of acid reflux. We might prove this one by looking at sales of antacids and acid blockers against carb consumption, but from my own experience (and the related clinical experience of Dr. Atkins and the Eadeses), we're pretty sure about this. Carbs cause acid reflux. Stomach acid where it doesn't belong cannot be a good thing. It hurts. But could it be doing damage, effectively diverting the immune system from fighting newlyn tumors? I'm not disagreeing about the headline probably being over stated, but at the same time, it's pretty easy to see how it might work. So, you elect to add an unsubstantiated hypothesis for "clarification" purposes. Did you read the actual abstract as published by the study authors? Or did you manage to just read the PR Press Release issued by the publishers nearly 60 days after the actual publication? I enjoy your "mastermind" at work. Did you ever apologize to the other poster about the McDonald's dish that you insisted wasn't there anymore? I thought so. |
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Study Details Link Between Obesity, Carbs and Esophageal Cancer
On Tue, 26 Feb 2008 07:56:12 -0600, Jim
wrote: Esophageal cancer rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001. The headline is probably overstated.... there is a statistical association here, not a cause and effect. I doubt at all that it's overstated. I had chronic heartburn and severe acid reflux for most of my adult life. I ate Rolaids like candy, then took Zantac once or twice a day when it came out. I still had reflux, and would often wake up in the night gagging on my own vomit, Within days after I started my low carb way of eating, the heartburn disappeared. Within a few weeks, the acid reflux had completely gone away. It's been probably two years now since I had heartburn, and that was only when I went off my LC WOE for a day or ate something carby that I shouldn't have. And there is not question that acid reflux is the main cause of esophageal cancer. No, I don't think the headline is overstated at all! I'm ore surprised that someone hasn't pointed this out sooner. Cleveland, Ohio – February 25, 2008 – Cases of esophageal cancer (adenocarcinoma) in the U.S. have risen in recent decades from 300,000 cases in 1973 to 2.1 million in 2001 at age-adjusted rates. A new study published in The American Journal of Gastroenterology shows that these rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001. --- Peter 270/227/180 |
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Study Details Link Between Obesity, Carbs and Esophageal Cancer
On Tue, 26 Feb 2008 09:35:22 -0600, Jim
wrote: Hollywood wrote: On Feb 26, 7:56 am, Jim wrote: Esophageal cancer rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001. The headline is probably overstated.... there is a statistical association here, not a cause and effect. ================================================== === http://www.blackwellpublishing.com/p...m.asp?ref=1632 Hrm. Let's see if we can come up with a causative story. Just there is correlation doesn't mean there ISN'T causation. When I eat too many carbs, I, like many people, get vary degrees of acid reflux. We might prove this one by looking at sales of antacids and acid blockers against carb consumption, but from my own experience (and the related clinical experience of Dr. Atkins and the Eadeses), we're pretty sure about this. Carbs cause acid reflux. Stomach acid where it doesn't belong cannot be a good thing. It hurts. But could it be doing damage, effectively diverting the immune system from fighting newlyn tumors? I'm not disagreeing about the headline probably being over stated, but at the same time, it's pretty easy to see how it might work. So, you elect to add an unsubstantiated hypothesis for "clarification" purposes. "Unsubstantiated?" You're idiotic. You're talking stupidly about something of which you apparently have no knowledge at all -- without even doing basic research to verify your dumb statements. Did you read the actual abstract as published by the study authors? Or did you manage to just read the PR Press Release issued by the publishers nearly 60 days after the actual publication? Um, it's *you* who are talking out your substantial butt. Chronic acid reflux has long been known to be a major cause of esophageal cancer, and excess carbs cause acid reflux. http://medicineworld.org/cancer/lead...al-cancer.html http://www.mayoclinic.com/health/eso...500/DSECTION=3 http://www.newswise.com/articles/view/531123/ http://www.medicalnewstoday.com/articles/49864.php http://www.suite101.com/article.cfm/...atments/103693 http://www.webmd.com/cancer/news/200...phageal-cancer --- Peter 270/227/180 |
#6
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Study Details Link Between Obesity, Carbs and Esophageal Cancer
"Marengo" wrote wrote: Esophageal cancer rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001. The headline is probably overstated.... there is a statistical association here, not a cause and effect. I doubt at all that it's overstated. I had chronic heartburn and severe acid reflux for most of my adult life. I ate Rolaids like candy, then took Zantac once or twice a day when it came out. I still had reflux, and would often wake up in the night gagging on my own vomit, Within days after I started my low carb way of eating, the heartburn disappeared. Within a few weeks, the acid reflux had completely gone away. It's been probably two years now since I had heartburn, and that was only when I went off my LC WOE for a day or ate something carby that I shouldn't have. And there is not question that acid reflux is the main cause of esophageal cancer. No, I don't think the headline is overstated at all! I'm ore surprised that someone hasn't pointed this out sooner. I had a similar experience which was cured (or controlled) by LC. That reflux will definitely mess you up. |
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Study Details Link Between Obesity, Carbs and Esophageal Cancer
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#8
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Study Details Link Between Obesity, Carbs and Esophageal Cancer
On Feb 26, 9:35 am, Jim wrote:
Hollywood wrote: On Feb 26, 7:56 am, Jim wrote: Esophageal cancer rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001. The headline is probably overstated.... there is a statistical association here, not a cause and effect. ================================================== === http://www.blackwellpublishing.com/p...m.asp?ref=1632 Hrm. Let's see if we can come up with a causative story. Just there is correlation doesn't mean there ISN'T causation. When I eat too many carbs, I, like many people, get vary degrees of acid reflux. We might prove this one by looking at sales of antacids and acid blockers against carb consumption, but from my own experience (and the related clinical experience of Dr. Atkins and the Eadeses), we're pretty sure about this. Carbs cause acid reflux. Stomach acid where it doesn't belong cannot be a good thing. It hurts. But could it be doing damage, effectively diverting the immune system from fighting newlyn tumors? I'm not disagreeing about the headline probably being over stated, but at the same time, it's pretty easy to see how it might work. So, you elect to add an unsubstantiated hypothesis for "clarification" purposes. Different methodology at work, Jim. I forgot to add the usual thank you for the study. I always find them interesting. But, back to the matter at hand. You like to look at the studies. I like to try and understand the world. Understanding means putting forth hypotheses. They all start unsubstantiated. Then they get tested and disproved. My "unsubstantiated hypothesis" would be a useful avenue for further study by these folks. So, they found a correlation. Next, look for causation. Maybe you need to brush up on your scientific method and your study design. Did you read the actual abstract as published by the study authors? I read what you posted. Or did you manage to just read the PR Press Release issued by the publishers nearly 60 days after the actual publication? I read what you posted. I enjoy your "mastermind" at work. I'm glad you do. Did you ever apologize to the other poster about the McDonald's dish that you insisted wasn't there anymore? WTF are you talking about? Link please. I thought so. And you are always right, so never have to apologize. To avoid further confusion, you should probably change your posting name to "Perfect Jim." For the love of God. PS- Keep the studies coming. The interpretation too. I like you. No sarcasm. |
#9
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Study Details Link Between Obesity, Carbs and Esophageal Cancer
On Feb 26, 8:24 pm, MoiMoi wrote:
In article , says... "Marengo" wrote wrote: Esophageal cancer rates in the U.S. closely mirrored trends of increased carbohydrate intake and obesity from 1973-2001. The headline is probably overstated.... there is a statistical association here, not a cause and effect. I doubt at all that it's overstated. I had chronic heartburn and severe acid reflux for most of my adult life. I ate Rolaids like candy, then took Zantac once or twice a day when it came out. I still had reflux, and would often wake up in the night gagging on my own vomit, Within days after I started my low carb way of eating, the heartburn disappeared. Within a few weeks, the acid reflux had completely gone away. It's been probably two years now since I had heartburn, and that was only when I went off my LC WOE for a day or ate something carby that I shouldn't have. And there is not question that acid reflux is the main cause of esophageal cancer. No, I don't think the headline is overstated at all! I'm ore surprised that someone hasn't pointed this out sooner. I had a similar experience which was cured (or controlled) by LC. That reflux will definitely mess you up. Yep, my reflux gone within days of doing Atkins induction level, several years ago. MM I'm going to add to that. Reading Marengo on it is like my story, if he were younger and less far along the path. Sub Tums with whatever Acid Blocker they come with in the big bottle, and that was my candy. On top of the other candy. |
#10
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Study Details Link Between Obesity, Carbs and Esophageal Cancer
On Feb 26, 9:35 am, Jim wrote:
Hollywood wrote: Did you ever apologize to the other poster about the McDonald's dish that you insisted wasn't there anymore? No need for the link. I figured out what you were talking about. It is me who deserves your apology. The OP and I were talking about a company that was once owned by McDonalds. http://www.chipotle.com/ (requires flash) You mistakenly thought we were talking about a menu item. Go back to that thread, as the full explanation is there. I thought so. When YOU apologize to ME for: 1- The other thread where you have wronged me through your own misunderstanding and 2- This thread, where Marengo has countered your vicious attack on me with more studies demonstrating the logic chain between obesity, carbs, reflux, and cancer (which I had actually picked up from Mike Eades Blog I dunno when, so didn't have the studies, just the understanding). At that point, all is square. Till then, you're in the wrong. Sorry. |
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